Abbreviations

ACMG – American College of Medical Genetics and Genomics
ADC – Antibody Drug Conjugate
AMP – Association for Molecular Pathology
BRCA – Breast Cancer
CDK4/6 – Cyclin Dependent Kinases 4 and 6
CPS – Combined Positive Score
EGFR – Epidermal Growth Factor Receptor
EMA – European Medicines Agency
ER/PR – Estrogen Receptor/Progesterone Receptor
GenDG – Genetic Diagnostics Act
GnRH – Gonadotropin Releasing Hormon
HER2 – Human Epidermal growth factor Receptor 2
HR – Hormone Receptor
HGVS – Human Genome Variant Society
IARC – International Agency for Research on Cancer
IC – Immune Cell
ICI – Immune Checkpoint Inhibitors
IHC – Immunohistochemistry
IKWG – The International Ki67 in Breast Cancer Working Group
ISH – In Situ Hybridization
Ki67 – Antigen Ki-67
MAPK – Mitogen Activated Protein Kinase
mBC – metastatic Breast Cancer
MCC – MCC bridge
mTNBC – metastatic Triple Negative Breast Cancer
NGS – Next Generation Sequencing
NSCLC – Non Small Cell Lung Cancer
PARP – Poly ADP Ribose Polymerase
PD-1 – Programmed Death Protein 1
PD-L1 – Programmed Cell Death Ligand 1
PI3K – Phosphotidylinositol 3-Kinases
PTEN – Phosphatase and TENsin homolog
QuIP – Qualitätssicherungs-Initiative Pathologie GmbH
SERM – Selective Modulator of Estrogen Receptors (SERM)
SLNB – Sentinel Lymph Node Biopsy
SOP – Standard Operating Procedure
TNBC – Triple Negative Breast Cancer
VUS – Variants of Unknown Significance